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Troponin
Foundation for Responsible Use of Troponin
Welcome
Terminology
MI Types 1, 2, 3, 4, and 5
Type 1 vs 2 MI
Myocardial injury vs ischemia
STEMI and NSTEMI
Multiple Contributors
High-sensitivity
Top Ten Takeaway Points
Biochemistry
Isoforms of Troponin
Timecourse of Isoforms
Reference Limit Definitions
Generations of Troponin Assays
What is “high-sensitivity”?
False Positives
False Negatives
Probability
Talking about Conditional Probabilities
Fundamentals
Positive and Negative Predictive Value
Sensitivity and Specificity
Example: Positive Predictive Value
Spectrum bias
Bayes’ Theorem
Example: Using Likelihood Ratios
When Not to Be Reassured
Situations Affecting Troponin Accuracy
Where Troponins Guide Decisions in ACS
Troponin Elevations and Recognizing Myocardial Necrosis
The STEMI Framework for Identifying ACO
Journal Club
Árnadóttir (2020, Circulation)
Pickering (2017, Annals of IM)
Lang (2022, Brown J Hosp Med)
Sengupta (2023, EHJ Digital Health)
Vignettes
About
Team
Take the Survey
Collaborators
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