The interpretation of abnormal Tn levels is both a science and an art that hinges on a careful consideration of findings from electrocardiographic, echocardiographic, physical exam, interview, and other imaging and laboratory data to formulate a weighted differential diagnosis. Here, we review the spectrum of cardiac and non-cardiac etiologies of abnormal serum Tn, as well as the epidemiology, mechanisms, and prognostic implications of each condition. Given the wealth of resources focused on ACS in existence, our website will focus on non-ACS etiologies of Tn elevation.

Etiologies of troponin elevation associated with different organ systems. Original figure designed in BioRender.

Read about the Cardiovascular Etiologies of Troponin Elevation